Um, “fail”.

building 'pycurl' extension
creating build/temp.macosx-10.3-i386-2.5
creating build/temp.macosx-10.3-i386-2.5/src
-DNDEBUG -g -fwrapv -O3 -Wall -Wstrict-prototypes
 -I/opt/local/include -I/opt/local/include/python2.5
 -c src/pycurl.c -o
 build/temp.macosx-10.3-i386-2.5/src/pycurl.o
unable to execute -DNDEBUG: No such file or directory
error: command '-DNDEBUG' failed with exit status 1