The Shinagawa Prince hotel is…okay, with short, stiff beds (one crunchy pillow each), extremely small rooms, and over-priced restaurants. It does have a decent convenience store, and the 24-hour pizza/pasta place is reasonably priced and turns into a breakfast shop in the morning. Its real virtue is location: a short walk from Shinagawa Station, from which you can go pretty much anywhere in the country.
And, if your room is on the north side, the view is worthwhile.