Do not wear power armor when starting the quest The Nuclear Option. The only “workaround” is to revert to your previous manual save. (my autosaves and quicksaves somehow ended up all being after the critical point, and this is not uncommon due to the way the save system works).

The other glitch I ran into getting to the final quest involved Tinker Tom’s piloting skills; somehow the “land the vertibird” trigger failed to go off, and he kept flying in a straight line, right off the edge of the world. Fortunately, the autosave had no opportunity to wreck that one, and I was able to just redo that one quest stage.